biodistribution of [64cu]pyruvaldehyde-bis (n4-methylthiosemicarbazone) complex in fibrosarcoma-bearing rats [persian]
نویسندگان
چکیده
introduction: 64cu-pyruvaldehyde-bis(n4-methylthiosemicarbazone) (64cu-ptsm) is one of the most important copper radiopharmaceuticals used in clinical experiments. methods: in this work, copper-64 (t1/2=12.33 h) production has been presented followed by the synthesis of the complexing agent, ptsm, and its structure was confirmed by common spectroscopic methods followed by radiolabeling with 64cu-actetate. the tracer was finally administered to fibrosarcoma-bearing rats and the biodistribution was determined in critical tissues as well as tumor. results: the final radiopharmaceutical solution underwent common quality control tests for animal injection a radiochemical purity >95% was determined. a significant tracer tumor uptake was observed 2 hours post injection. tumor:muscle and tumor:blood ratios were shown to be 8 and 6 respectively. conclusion: 64cu-ptsm prepared in this report is a good candidate for tumor therapy as well as diagnosis for national use.
منابع مشابه
Biodistribution of [64Cu]pyruvaldehyde-bis (N4-methylthiosemicarbazone) complex in fibrosarcoma-bearing rats [Persian]
Introduction: 64Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (64Cu-PTSM) is one of the most important copper radiopharmaceuticals used in clinical experiments. Methods: In this work, copper-64 (T1/2=12.33 h) production has been presented followed by the synthesis of the complexing agent, PTSM, and its structure was confirmed by common spectroscopic methods followed by radiolabeling w...
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عنوان ژورنال:
iranian journal of nuclear medicineناشر: tehran university of medical sciences
ISSN 1681-2824
دوره 15
شماره 1 2007
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